Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma
نویسندگان
چکیده
The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior ample evidence links cell intercommunication to nanomaterial size. However, little is known about effect of geometry on behavior. To elucidate this extend application cancer theranostics, we have engineered core–shell cobalt–gold nanoparticles with spherical (Co@Au NPs) elliptical morphology NEs). Our results show that owing superparamagnetism, Co@Au NPs can generate hyperthermia upon magnetic field stimulation. In contrast, due geometric difference, NEs be optically excited photostimulation elevate medium temperature 45 °C. Both geometries employed as prospective contrast agents; however, identical concentration, exhibited 4-fold higher cytotoxicity L929 fibroblasts compared NEs, confirming fate. Furthermore, photostimulation-generated prompted detachment anti-cancer drug, Methotrexate (MTX), from NEs-MTX complex which triggered 90% decrease SW620 colon carcinoma viability, their theranostics. geometry-based perturbation fate profound impact our understanding nano-bio interface exploited for engineering materials optimized superior theranostic applications.
منابع مشابه
In vitro toxicological assessment of MgO and Silica Nanoparticle in human colon carcinoma cells
The use of nanoparticles (NPs) has been extended to many fields such as agriculture, food industry, medicine and biotechnological fields. Thereby, human exposure to NPs consequently increases. Therefore, there is a concern about the potential biological effects and toxicity of NPs for humans and the environment. This study aimed to investigate the cytotoxicity effects of magnesium oxide (MgO) a...
متن کاملMagnetic Nanoparticle-Based Theranostics
This theme issue provides a timely collection of studies on magnetic nanoparticle-based imaging, bio-sensing, therapy and/or their combinations.
متن کاملMultifunctional magnetoplasmonic nanoparticle assemblies for cancer therapy and diagnostics (theranostics).
In this work, we describe the preparation and biomedical functionalities of complex nanoparticle assemblies with magnetoplasmonic properties suitable for simultaneous cancer therapy and diagnostics (theranostics). Most commonly magnetoplasmonic nanostructures are made by careful adaptation of metal reduction protocols which is both tedious and restrictive. Here we apply the strategy of nanoscal...
متن کاملstudy of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanomaterials
سال: 2021
ISSN: ['2079-4991']
DOI: https://doi.org/10.3390/nano11082048